Effect of oral antihypertensive drugs on biochemical dosages in the elderly

Maria Elizana Martins de Meneses Carvalho, Eucário Leite Monteiro Alves, Maria do Carmo de Carvalho e Martins


Objective: to compare serum levels of uric acid, glucose, potassium and sodium in elderly users and non-users of oral antihypertensive drugs. Methods: observational, case-control study, including 232 elderly people with mean age 68.9 ± 7.4 years, of which 116 use and 116 do not use oral antihypertensive drugs, of both genders, non-diabetic and with no renal disease. After venous blood collection, glucose and uric acid were measured by colorimetric method; and sodium and potassium by the ion-selective electrode method. Results: there was an association between use of antihypertensive drugs and elevations in serum uric acid levels (p=0.040). And, among the classes, diuretic drugs demonstrated in this study relation with changes in uric acid levels (p=0.02) when compared to the other classes. Conclusion:the use of antihypertensive drugs, especially diuretics, has been associated with an increase in serum uric acid levels in hypertensive users of oral antihypertensive drugs.


Aged; Antihypertensive Agents; Drug-Related Side Effects and Adverse Reactions. 

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DOI: http://dx.doi.org/10.15253/rev%20rene.v17i6.18850


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