Factors related to mortality by pneumonia unrelated to mechanical ventilation

Keywords: Pneumonia; Mortality; Cross Infection; Hospital Mortality.

Abstract

Objective: to analyze the factors related to mortality by nosocomial pneumonia unrelated to mechanical ventilation. Methods: retrospective cohort study with a sample acquired using the 538 notification forms for health care-related infections. The relative risk was calculated and a multivariable analysis was carried out using Poisson regression with a significance level of 5%. Results: the multivariable analysis showed that being under 59 years old and taking only one antimicrobial drug were protective factors against death. The main microorganisms responsible for the increase in the risk of death were: Acinetobacter baumannii, Klebsiella pneumoniae and species of Candida (Candida spp). Conclusion: the factors related to mortality were being 60 years old or older, using two or more antimicrobial substances, and being affected by the microorganisms Acinetobacter baumannii, Klebsiella pneumonia, and species of Candida (Candida spp).


References

Organização Pan-Americana da Saúde. 10 principais causas de morte no mundo [Internet]. 2018 [cited Jan 10, 2021]. Available from: https://www.paho.org/bra/index.php?option=com_content&view=article&id=5638:10-principais-causas-de-morte-no-mundo&Itemid=0

Assunção RG, Pereira WA, Nogueira FJR, Dutra IL, Novais TMG, Abreu AG. Antimicrobial resistance of microorganisms causing pneumonia in patients of a public hospital in Brazilian Pre-Amazon Region. J Pharm Pharmacol. 2019; 7(1):15-21. doi: https://www.researchgate.net/publication/330257157

Micek ST, Chew B, Hampton N, Kollef MH. A case-control study assessing the impact of non-ventilated hospital-acquired pneumonia on patient outcomes. Chest. 2016; 150(5):1008-14. doi: https://doi.org/10.1016/j.chest.2016.04.009

Baker D, Quinn B. Hospital acquired pneumonia prevention initiative-2: incidence of no ventilator hospital-acquired pneumonia in the United States. Am J Infect Control. 2018; 46(1):2-7. doi: https://doi.org/10.1016/j.ajic.2017.08.036

Soares GSC, Mascarenhas MDM, Moura LNB, Pereira AFM. Caracterização das infecções relacionadas à assistência à saúde em um hospital de ensino do Nordeste do Brasil. Rev Enferm UFPI. 2017; 6(2):37-43. doi: https://doi.org/10.26694/reufpi.v6i2.5933

Di Pasquale M, Alberti S, Mantero M, Bianchini S, Blasi F. Non-intensive care unit acquired pneumonia: a new clinical entity? Int J Mol Sci. 2016; 17(3):287. doi: https://doi.org/10.3390/ijms17030287

Figueiredo ML, Silva CSO, Brito MFSF, D’Innocenzo, M. Analysis of incidents notified in a general hospital. Rev Bras Enferm. 2018; 71(1):121-30. doi:https://dx.doi.org/10.1590/0034-7167-2016-0574

Pássaro L, Harbarth S, Landelle C. Prevention of hospital-acquired pneumonia in non-ventilated adult patients: a narrative review. Antimicrob Resist Infect Control. 2016; 5:43. doi: http://dx.doi.org/10.1186/s13756-016-0150-3

Ribeiro LSC, Santana TJA, Reis NA, Silveira GHCF, Côrrea RA, Mancuzo EV. Fatores de risco e incidência de Pneumonia Hospitalar em Unidade de Internação. Braz J Health Rev. 2019; 2(5):4866-75. doi: http://dx.doi.org/10.34117/bjhr2n5-083

Giuliano KK, Baker D, Quinn B. The epidemiology of nonventilator hospital-acquired pneumonia in the United States. Am J Infect Control. 2018; 46(3):322-7. doi: https://dx.doi.org/10.1016/j.ajic.2017.09.005

Kalil AC, Metersky ML, Klompas M, Muscerede J, Sweeney DA, Palmer LB, et al. Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the infectious diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016; 63(5):e61-e111. doi: http://dx.doi.org/10.1093/cid/ciw353

Gomes RFT, Castelo EF. Hospital dentisty and the occurrence of pneumonia. Rev Gaúcha Odontol. 2019; 6:67. doi: http://dx.doi.org/10.1590/1981-86372019000163617

Guillamet CV, Kollef MH. Acinetobacter pneumonia: improving outcomes with early identification and appropriate therapy. Clin Infect Dis. 2018; 67(9):1455-62. doi: https://dx.doi.org/10.1093/cid/ciy375

Martin RM, Bachman MA. Colonization, infection, and the accessory genome of Klebsiella pneumoniae. Front Cell Infect Microbiol. 2018; 8:4. doi: http://dx.doi.org/10.3389/fcimb.2018.00004

Huang D, Qi M, Hu Y, Yu M, Liang Z. The impact of Candida spp airway colonization on clinical outcomes in patients with ventilator-associated pneumonia: a systematic review and meta-analysis. Am J Infect Control. 2019; 48(6):695-701. doi: http://dx.doi.org/10.1016/j.ajic.2019.11.002

Sousa AFL, Queiroz AAFLN, Oliveira LB, Moura LKB, Andrade D, Watanabe E, et al. Deaths among the elderly with ICU infections. Rev Bras Enferm. 2017; 70(4):766-72. doi: https://dx.doi.org/10.1590/0034-7167-2016-0611

Nunes BP, Soares UM, Wachs LS, Volz PM, Saes MO, Silva Duro SM, et al. Hospitalização em idosos: associação com multimorbidade, atenção básica e plano de saúde. Rev Saúde Pública. 2017; 51(43):1-10. doi: http://doi.org/10.1590/s1518-8787.2017051006646

Tesoro M, Peyser DJ, Villarente FA. Retrospective study of non-ventilator-associated hospital acquired pneumonia incidence and missed opportunities for nursing care. J Nurs Adm. 2018; 48(5):285-91. doi: http://doi.org/10.1097/NNA.0000000000000614

Brabo BCF, Zeitoun SS. Pneumonia associada à ventilação mecânica: avaliação do conhecimento da equipe de enfermagem de uma terapia intensiva. Arq Med Hosp Fac Cienc Med Santa Casa São Paulo. 2017; 62(3):130-8. doi: https://doi.org/10.26432/1809-3019.2017.62.3.130

Published
2021-06-09
Section
Research Article