A proposed waist-to-height ratio (WtHR) cutoff point for metabolic risk in Brazilian Turner syndrome patients

  • Samantha Dodt Farias Universidade Federal do Ceará (UFC) http://orcid.org/0000-0002-0217-4958
  • Eveline Gadelha Pereira Fontenele Universidade Federal do Ceará (UFC)
  • Rosana Quezado Universidade Federal do Ceará (UFC)
  • Ana Rosa Pinto Quidute Universidade Federal do Ceará (UFC)
  • Ludmilla Aline Guimarães Moreira Farias Universidade Federal do Ceará (UFC)
  • Tamires Morita Universidade Federal do Ceará (UFC)
  • Camila Sâmea Monteiro Bezerra Universidade Federal do Ceará (UFC)
Palavras-chave: Waist-height Ratio, Turner syndrome, Metabolic syndrome

Resumo

Objective: To propose a waist-to-height ratio (WtHR) cutoff point for metabolic risk in Brazilian Turner syndrome (TS) patients. Methods: Retrospective study of anthropometric, clinical and biochemical data related to the metabolic syndrome (MS) of 45 TS patients at a specialized center. The accuracy and area under the receiver operating characteristic (ROC) curve of body mass index (BMI), waist circumference (WC) and WtHR to identify the presence of at least one of the biochemical components of MS were calculated. Results: The average age was 23.8 years (4-61 years), 43% were overweight and 11% had MS. At least one component of MS was present in 80% of the patients, being more common central obesity, low levels of HDL and dysglycemia. None had diabetes. Patients with some of the biochemical changes in MS had higher WtHR than those without metabolic alterations (0.57 vs. 0.48, P = 0.001). In adult patients (20-61 years, n = 28) the WtHR > 0.5 had 87% sensitivity and 80% specificity to identify patients with some component of MS, demonstrating greater accuracy than BMI or WC. Conclusion: We propose a WtHR cutoff point of 0.5 for metabolic risk screening in Brazilian TS patients.

Biografia do Autor

Samantha Dodt Farias, Universidade Federal do Ceará (UFC)
Endocrine fellow at Hospital Universitário Walter Cantídio (HUWC).
Eveline Gadelha Pereira Fontenele, Universidade Federal do Ceará (UFC)
PhD in Biotechnology, Adjunct Professor, Department of Clinical Medicine, Coordinator of the Center of Multidisciplinary Support for Turner’s syndrome patients, Universidade Federal do Ceará (UFC).
Rosana Quezado, Universidade Federal do Ceará (UFC)

Master’s degree in Medical Surgical Sciences, Preceptor Physician at the Endocrinology and Metabolism Service, Hospital Universitário Walter Cantídio (HUWC).

Ana Rosa Pinto Quidute, Universidade Federal do Ceará (UFC)

PhD in Pharmacology, Adjunct Professor, Department of Physiology and Pharmacology, Universidade Federal do Ceará (UFC).

Ludmilla Aline Guimarães Moreira Farias, Universidade Federal do Ceará (UFC)

Médica Pesquisadora do Serviço de Endocrinologia do Hospital Universitário Walter Cantídio, Residência em Endocrinologia e Metabologia, Universidade Federal do Ceará (UFC).

Tamires Morita, Universidade Federal do Ceará (UFC)
Intern of Medicine, Hospital Universitário Walter Cantídio (HUWC).
Camila Sâmea Monteiro Bezerra, Universidade Federal do Ceará (UFC)
Intern of Medicine, Hospital Universitário Walter Cantídio (HUWC).
Publicado
2018-12-26
Seção
ARTIGOS ORIGINAIS