Rectal distention increases the frequency and duration of transient lower esophageal sphincter relaxations in anesthetized dogs– a putative rectoesophageal reflex

Auteurs

  • Jose Ronaldo Vasconcelos Graça Universidade Federal do Ceará (UFC)
  • Jose Ricardo Cunha Neves Universidade Federal do Ceará (UFC)
  • Sidney Wendell Goiana da Silva Universidade Federal do Ceará (UFC)
  • Willy Okoba Universidade Federal do Ceará (UFC)

DOI :

https://doi.org/10.20513/2447-6595.2019v59n3p24-31

Mots-clés :

Esophago-gastric junction, Rectum, Dogs

Résumé

Introduction: The esophagus is subject to frequent reflux of gastric contents as a normal phenomenon during episodes of transient lower esophageal sphincter relaxation (tLESR), responsible too, for pathologic reflux. However, pathologic reflux is mostly associated with reflux of acid contents. Distending the stomach provokes an increase in frequency of tLESR. Objective: To investigate the effect of distending the rectum on the tLESR and possible involved pathways. Methods: Forty four (Protocol: 096/07) street dogs were selected and divided into respective protocols: Rectal distention (RD), Gastric distention (GD), RD+GD, Atropine+RD, Hexamethonium+RD, Baclofen+RD, Bilateral Pudendal nerve section+RD and Spinal cord transection+RD. We determined and compared the tLESR of each group and subjected data to statistical analysis. Values of p<0.05 were regarded as statistically significant. Results: RD provoked a significant increase in the tLESR just as GD, with RD+GD provoking the highest value of tLESR. This increase in tLESR due to RD was prevented in A+RD, B+RD, Bilateral Pudendal nerve section+RD and Spinal cord transection+RD but not Hexamethonium+RD protocols. Conclusion: RD is a significant inducer of an increase in tLESR with participation of muscharinic and GABAβ, sensitive and spinal cord neurons, but not nicotinic receptors.

Bibliographies de l'auteur

Jose Ronaldo Vasconcelos Graça, Universidade Federal do Ceará (UFC)

M.D, PhD-Pharmacology Federal University of Ceará, Campus Porangabussu. Assistant Professor- Faculty of Medicine and Department of Post-graduation in Biotechnology – Federal University of Ceará, Campus in Sobral - Brazil.

Jose Ricardo Cunha Neves, Universidade Federal do Ceará (UFC)

Possui graduação em Medicina pela Universidade Federal do Ceará (1989) e mestrado em Cirurgia pela Universidade Federal do Ceará (2006), concluiu Doutorado pela UFC em 2013 e também Professor Adjunto I da Faculdade de Medicina da Universidade Federal do Ceará, Campus Sobral, Médico Cirurgião - Santa Casa de Mirsericórdia de Sobral, Médico Cirugião e Endoscopista na Clinica Cirurgica e Endoscopica Dr. Neves. Tem experiência na área de Cirugia Geral, Cirurgia laparoscopica, Endoscopia Diagnostico e Terapeutca com ênfase em Cirurgia Experimental, atuando principalmente com motilidade gastroinntestinal.

 

Sidney Wendell Goiana da Silva, Universidade Federal do Ceará (UFC)

Federal University of Ceara, Campus in Sobral- Ceará- Brazil.

Willy Okoba, Universidade Federal do Ceará (UFC)

Médico Generalista, natural do Quênia, mas atualmente reside no Brasil. Graduado em medicina pela Faculdade de Medicina da Universidade Federal do Ceara em 2012. Registrado pelo Conselho Regional de Medicina do estado do Ceará e Distrito Federal. Registrado também pela Ordem dos Médicos e Dentistas Registrados da Republica do Quênia (Kenya Medical Practitioners and Dentists Board). Concluiu o curso de Pós-graduação em Cirurgia Geral, Hospital Santa Casa de Misericórdia de Sobral. Concomitante, está envolvido em pesquisa cientifica investigando a taxa de esvaziamento gástrico em pacientes com insuficiência renal aguda (IRA).

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Publiée

2019-09-13

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ARTIGOS ORIGINAIS