Toxicidade financeira e nível de distress em indivíduos submetidos ao transplante de células tronco hematopoiéticas

Jamille Maria Lima Vieira; Luciana Puchalski Kalinke; Yasmin Paulina Dourado Vissintainer; Gisele Cordeiro Castro; Maria de Fátima Mantovani; Sonia Silva Marcon; Luciana de Alcantara Nogueira

doi:10.36517/2175-6783.20252694616

Authors

Jamille Maria Lima Vieira Universidade Federal do Paraná https://orcid.org/0000-0003-1044-8629
Luciana Puchalski Kalinke Universidade Federal do Paraná https://orcid.org/0000-0003-4868-8193
Yasmin Paulina Dourado Vissintainer Universidade Federal do Paraná https://orcid.org/0000-0002-5249-3308
Gisele Cordeiro Castro Universidade Federal do Paraná https://orcid.org/0000-0002-9643-4174
Maria de Fátima Mantovani Universidade Federal do Paraná https://orcid.org/0000-0001-7961-8273
Sonia Silva Marcon Universidade Estadual de Maringá https://orcid.org/0000-0002-6607-362X
Luciana de Alcantara Nogueira Universidade Federal do Paraná https://orcid.org/0000-0002-5985-7418

DOI:

https://doi.org/10.36517/2175-6783.20252694616

Keywords:

Bone Marrow Transplantation; Financial Stress; Hematologic Neoplasms; Psychological Distress.

Abstract

Objective: to identify the financial toxicity and distress level of patients with hematological cancers undergoing Hematopoietic Stem Cell Transplantation. Methods: this is a descriptive, cross-sectional study, conducted with 21 patients admitted to a Bone Marrow Transplant Service. The following questionnaires were applied for data collection: sociodemographic; Comprehensive Score for Financial Toxicity; and Distress Thermometer, with descriptive statistical analysis and Spearman’s correlation being performed using R software version 4.1.0 (R- Core Team 2021). Results: the average financial toxicity score was 24.6, indicating grade 1 and mild impact. In contrast, the distress level found was 5.3, indicating a high degree of distress (>4). There is a weak and positive correlation between financial toxicity and distress (ρ=0.45, p<0.05). Conclusion: grade 1 financial toxicity and high distress levels were identified in patients undergoing hematopoietic stem cell transplantation. Contributions to practice: identifying factors which may be related to patient suffering can support improvements in care.

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References

Ferreira ROS, Moura AR, Lima CA, Silva MA. Mortality trend from hematological cancers in Sergipe and its geospatial distribution from 1980 to 2021. Rev Bras Cancerol. 2024;70(3):e-134699. doi: https://dx.doi.org/10.32635/2176-9745.RBC.2024v70n3.4699

Instituto Nacional do Câncer. Tratamento do câncer [Internet]. 2022 [cited Dec 10, 2024]. Available from: https://www.gov.br/inca/pt-br/assuntos/cancer/tratamento/

Magedanz L, Leal JV, Santos BL, Brito ES, Saavedra PA, Soares LS, et al. Hematopoietic stem cell transplantation: inequities in distribution in Brazilian territory, 2001 to 2020. Ciênc Saúde Coletiva. 2022;27(8):3239-47. doi: https://doi.org/10.1590/1413-81232022278.03142022

Vigarinho MES, Domenico EBL, Matsubara MGS. Quality of life of onco-hematological cancer survivors undergoing hematopoietic stem cell transplantation: an integrative literature review. Rev Bras Cancerol. 2022;68(4):e-212708. doi: https://dx.doi.org/10.32635/2176-9745.RBC.2022v68n4.2708

Almeida AC, Azevedo VD, Alves TR, Santos VE, Silva GW, Azevedo IC. Common mental disorders in hematopoietic stem cell transplant patients: a scoping review. Rev Bras Enferm. 2024;77(1):e20220581. doi: http://doi.org/10.1590/0034-7167-2022-0581pt

Abrams HR, Durbin S, Huang CX, Johnson SF, Nayak RK, Zahner GJ, et al. Financial toxicity in cancer care: origins, impact, and solutions. Transl Behav Med. 2021;11(11):2043-54. doi: https://doi.org/10.1093/tbm/ibab091

Gordon LG, Elliott TM, Wakelin K, Leyden S, Leyden J, Michael M, et al. The economic impact on Australian patients with neuroendocrine tumours. Patient. 2020;13(3):363-73. doi: http://doi.org/10.1007/s40271-020-00412-z

Pisu M, Martin MY. Financial toxicity: a common problem affecting patient care and health. Nat Rev Dis Primers. 2022;8(1):2056-676X. doi: https://doi.org/10.1038/s41572-022-00341-1

Chen YS, Zhou ZN, Glynn SM, Frey MK, Balogun OD, Kanis M, et al. Financial toxicity, mental health, and gynecologic cancer treatment: the effect of the COVID-19 pandemic among low-income women in New York City. Cancer. 2021;127(14):2399-408. doi: https://doi.org/10.1002/cncr.33537

National Comprehensive Cancer Network. Guidelines Detail. Distress management [Internet]. 2024 [cited Dec 10, 2024]. Available from: https://www.nccn.org/professionals/physician_gls/pdf/distress.pdf

Nogueira LA, Koller FJ, Marcondes L, Mantovani MF, Marcon SS, Guimarães PRB, et al. Validation of the comprehensive score for financial toxicity for Brazilian culture. Ecancermedicalscience.2020;14:1158. doi: https://doi.org/10.3332/ecancer.2020.1158

Nogueira LA, Pimenta AM, Mantovani MF, Cordeiro HK, Silva LD, Kalinke LP. Financial toxicity and health-related quality of life among cancer patients: a correlational study. Aquichan. 2024;24(1):e2416. doi: https://doi.org/10.5294/aqui.2024.24.1.6

Riba MB, Donovan KA, Andersen B, Braun I, Breitbart WS, Brewe BW, et al. Distress Management, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2019;17(10):1229-49. doi: https://dx.doi.org/10.6004/jnccn.2019.0048

Decat CS, Laros JA, Araujo TC. Termômetro de Distress: validação de um instrumento breve para avaliação diagnóstica de pacientes oncológicos. Psico-USF. 2009;14(3):253-60. doi: https://doi.org/10.1590/s1413-82712009000300002

Honda K, Gyawali B, Ando M, Sugiyama K, Mitani S, Masuishi T, et al. A prospective survey of comprehensive score for financial toxicity in Japanese cancer patients: report on a pilot study. Ecancermedicalscience. 2018;12:847. doi: https://doi.org/10.3332/ecancer.2018.847

Oshiro NN, Nogueira LA, Santos YH, Guimarães PR, Kalinke LP. Quality of life and financial toxicity of hematopoietic stem cell transplant recipients in COVID-19. Rev Latino-Am Enfermagem. 2023;31:e3997. doi: https://dx.doi.org/10.1590/1518-8345.6688.3995

Santos MD, Lima FC, Martins LF, Oliveira JF, Almeida LM, Cancela MD. Estimativa de Incidência de Câncer no Brasil, 2023-2025. Rev Bras Cancerol. 2023;69(1):e-213700. doi: http://doi.org/10.32635/2176-9745.rbc.2023v69n1.3700

Yucel E, Zhang S, Panjabi S. Health-related and economic burden among family caregivers of patients with acute myeloid leukemia or hematological malignancies. Adv Ther. 2021;38(10):5002-24. doi: https://dx.doi.org/10.1007/s12325-021-01872-x

Hussaini SMQ, Ren Y, Racioppi A, Lew MV, Bohannon L, Johnson E, et al. Financial toxicity and quality of life in patients undergoing stem-cell transplant evaluation: a single-center analysis. JCO Oncol Pract. 2024;20(3):351-60. doi: https://doi.org/10.1200/OP.23.00243

Pail O, Knight TG. Financial toxicity in patients with leukemia undergoing hematopoietic stem cell transplantation: a systematic review. Best Pract Amp Res Clin Haematol. 2023;36(2):101469. doi: http://doi.org/10.1016/j.beha.2023.101469

Huerga RN, Diego IS, Jiménez CM, Martínez CM, Kwon M, García NP, et al. Financial toxicity in allogeneic haematopoietic stem cell transplant patients from a social determinants of health perspective. Eur J Oncol Nurs. 2024;70:102584. doi: https://doi.org/10.1016/j.ejon.2024.102584

Ouchveridze E, Banerjee R, Desai A, Aziz M, Lee-Smith W, Mian H, et al. Financial toxicity in hematological malignancies: a systematic review. Blood Cancer J. 2022;12(4):74. doi: https://doi.org/10.1038/s41408-022-00671-z

Zayat CG, Azevedo IM, Domenico EBL, Bergerot CD. Fatores preditores de sintomas emocionais e físicos reportados por pacientes oncológicos. Psic Teor Pesq. 2021;37:e37441. doi: https://doi.org/10.1590/0102.3772e37441

Flanagan MW, Goltz HH, Henson JW, Smith ML. Associations of practical, emotional, and physical problems with psychosocial distress among cancer patients. J Psychosoc Oncol. 2021;40(1):98-114. doi: https://doi.org/10.1080/07347332.2021.1899353

Yang M, Zhang Z. Nice EC, Wang C, Zhang W, Huang C. Psychological intervention to treat distress: an emerging frontier in cancer prevention and therapy. Biochim Biophys Acta Rev Cancer. 2022;1877(1):188665. doi: https://dx.doi.org/10.1016/j.bbcan.2021.188665

Paley CA, Boland JW, Santarelli M, Murtagh FE, Ziegler L, Chapman EJ. Non-pharmacological interventions to manage psychological distress in patients living with cancer: a systematic review. BMC Palliat Care. 2023;22(1):88. doi: https://doi.org/10.1186/s12904-023-01202-8

Silva LA, Guimarães PR, Marques AD, Marcondes L, Barbosa CS, Costa PC, et al. Effects of guided imagery relaxation in hematopoietic stem-cell transplantation patients: a quasi-experimental study. Rev Bras Enferm. 2022;75(5):e20220114. doi: https://doi.org/10.1590/0034-7167-2022-0114