Situação vacinal e desfecho clínico da COVID-19 em pacientes hospitalizados
DOI:
https://doi.org/10.36517/2175-6783.20252695529Palavras-chave:
COVID-19; Vacinas contra COVID-19; Hospitalização; Expectativas de Desfechos.Resumo
Objetivo: analisar a relação entre a situação vacinal de pacientes internados pela COVID-19 e os desfechos clínicos. Métodos: coorte retrospectiva realizada em um hospital de referência para a COVID-19, incluindo 305 pacientes ≥ 5 anos de idade internados em enfermarias e/ou unidades de terapia intensiva com diagnóstico da COVID-19. Dados de internação foram coletados em prontuários eletrônicos e dados da situação vacinal obtidos no sistema VaciVida. A análise foi realizada por modelos de regressão de Poisson. Resultados: a comparação entre pacientes sem nenhuma dose da vacina e aqueles que receberam dose de reforço apresentou risco relativo de 1,46 (p=0,160), sugerindo um aumento no risco de óbito entre os não vacinados, ainda que sem significância estatística. A comparação entre indivíduos sem vacinação e aqueles com esquema incompleto apresentou risco relativo de 2,42 (p=0,350). Conclusão: observou-se que a maioria dos pacientes que evoluíram para óbito ou necessitaram de cuidados intensivos não possuíam esquema vacinal completo, o que aponta para uma possível tendência a piores desfechos entre indivíduos não vacinados. Contribuições para a prática: os achados reforçam a importância da vacinação e vigilância ativa sobre fatores clínicos de gravidade para orientar condutas em pacientes com COVID-19.
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