Multimodal imaging of retinal astrocytic hamartoma in two patients with tuberous sclerosis complex

Abstract

Objective: To report the imaging methods used in the identification of retinal astrocytic hamartomas in two patients with Tuberous Sclerosis Complex. Methodology: Two female patients diagnosed with Tuberous Sclerosis Complex and retinal astrocytic hamartomas underwent ophthalmological and imaging exams, including color fundus photography, fluorescein angiography, optical coherence tomography (OCT), and optical coherence tomography-angiography (OCT-A). Results: Both patients presented retinal lesions characteristic of astrocytic hamartomas. OCT images revealed hyperreflective masses with retinal disorganization and the characteristic moth-eaten spaces. OCT-A showed increased vasculature within the lesions. Conclusion: Multimodal imaging, including OCT and OCT-A, proved useful in the detailed evaluation of retinal astrocytic hamartomas in patients with Tuberous Sclerosis Complex.