BIOLOGICAL ACTIVITY OF AQUEOUS AND ORGANIC EXTRACTS OF SEAWEEDS FROM CEARÁ STATE, BRAZIL

Autores/as

  • Márcia Rocha Torres Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brasil.
  • Alessandra de Paula Alves Sousa Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brasil.
  • Eduardo Augusto Torres da Silva Filho Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brasil.
  • Cláudia Pessoa Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brasil.
  • Maria Elisabete Amaral de Moraes Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brasil.
  • Manoel Odorico de Moraes Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brasil.
  • Letícia Veras Costa Lotufo Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brasil. Instituto de Ciências do Mar, Universidade Federal do Ceará, Fortaleza, CE, Brasil.

DOI:

https://doi.org/10.32360/acmar.v38i1-2.6393

Palabras clave:

marine macroalgae, cytotoxicity, hemolysis, sea urchin embryos, tumor cell lines

Resumen

The present study evaluated the biological activity of 12 marine macroalgae from Ceará State, Brazil. From the collected species 48 extracts (aqueous, dichloromethane, acetone and methanol extracts for each species) were obtained. The activity of extracts were rated at the following bioactivities: lethality in brine shrimp nauplii, inhibition of the development of sea urchin eggs, hemolytic activity on mice erythrocytes and inhibition of in vitro cellular proliferation on tumor cell lines using MTT assay. This study revealed that nine among the 12 tested species presented some activity in the applied assays, being that of the red algae Botryocladia occidentalis the most potent one The acetone extract obtained from B. occidentalis inhibited the growth of four out of five used tumor cell lines with an IC50 in the range of 5.0 to 24.5 μg/ml, possessed antimitotic activity on sea urchin eggs at concentrations up to 100 μg/ml, with no hemolylic activity and moderate toxicity to brine shrimp nauplii. Further studies are necessary for chemical characterization of the active principles and more extensive biological evaluation.

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Publicado

2017-02-09

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