Resistência antimicrobiana em biofilmes formados em dispositivos invasivos

Tomás Manuel Djú; Thaís Honório Lins Bernardo; Christefany Régia Braz Costa; Mirelle dos Santos; Yhasmin Santos Silva; Anny Gabrielly Santos Silva; Teresa Biussum Iurna

doi:10.36517/2175-6783.20262796142

Autores

Tomás Manuel Djú Universidade Federal de Alagoas https://orcid.org/0000-0001-6809-7230
Thaís Honório Lins Bernardo Universidade Federal de Alagoas https://orcid.org/0000-0002-8058-8400
Christefany Régia Braz Costa Universidade Federal de Alagoas https://orcid.org/0000-0001-6124-8243
Mirelle dos Santos Universidade Federal de Alagoas https://orcid.org/0000-0001-6540-7053
Yhasmin Santos Silva Universidade Federal de Alagoas https://orcid.org/0000-0003-2927-1931
Anny Gabrielly Santos Silva Universidade Federal de Alagoas https://orcid.org/0009-0004-2940-0806
Teresa Biussum Iurna Centro Universitário Mario Pontes Jucá de Maceió https://orcid.org/0009-0007-1017-1603

DOI:

https://doi.org/10.36517/2175-6783.20262796142

Palavras-chave:

Biofilmes; Equipamentos e Provisões; Infecção Hospitalar; Resistência Microbiana a Medicamentos.

Resumo

Objetivo: avaliar o perfil microbiológico e os padrões de resistência em biofilmes formados em dispositivos invasivos em pacientes de uma Unidade de Terapia Intensiva. Métodos: estudo de coorte prospectivo com 157 pacientes adultos em pós-operatório imediato. Foram analisados 275 dispositivos invasivos, coletados em condições assépticas, submetidos a cultivo microbiológico e testes de suscetibilidade. Utilizou-se testes de Qui-quadrado e Mann-Whitney. Resultados: houve formação de biofilmes em grande parte dos dispositivos, com isolamento de 200 microrganismos, principalmente Klebsiella pneumoniae (30%), Acinetobacter baumannii (25%) e Pseudomonas aeruginosa (20%). Foram identificados 48% de isolados multirresistentes, 19% extensivamente resistentes e 3% pan-resistentes. Observou-se elevada taxa de cateter venoso central com maior proporção de colonização por microrganismos multirresistentes (p<0,010). Em contraste com sondas vesicais de demora (p=0,072) e tubos orotraqueais (p=0,064). Conclusão: o perfil microbiológico em biofilmes de dispositivos invasivos incluiu principalmente bactérias gran negativas com amplo espectro de resistência a múltiplos antibióticos, impactando negativamente na segurança de paciente e qualidade de assistência. Contribuições para a prática: os resultados podem oferecer subsídios para o fortalecimento de estratégias preventivas e controle das infecções relacionadas à assistência à saúde, promovendo assim a segurança do paciente e qualidade de assistência prestada da unidade de terapia intensiva.

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