Custo da infecção primária de corrente sanguínea e dimensões de impacto: revisão de escopo
DOI:
https://doi.org/10.36517/2175-6783.20262796479Palavras-chave:
Pacientes; Infecções Relacionadas a Cateter; Custos Hospitalares; Programa de Controle de Infecção Hospitalar; Segurança do Paciente.Resumo
Objetivo: mapear o custo e dimensões do tratamento da infecção primária de corrente sanguínea em pacientes adultos e pediátricos. Métodos: revisão de escopo conduzida em cinco bases de dados, nacionais e internacionais, e três bases de literatura cinzenta. Resultados: dos 258 estudos identificados, 12 foram incluídos na amostra final. Os custos associados ao tratamento de infecções primárias da corrente sanguínea variaram de US$122,91 a US$439.015,00, com incremento no tempo de internação entre 10 e 135 dias. Na análise qualitativa, evidenciaram-se aumento da morbidade e de complicações relacionadas ao prolongamento da hospitalização, a necessidade de implementação de intervenções para mitigação de riscos e o elevado impacto financeiro para os sistemas de saúde. Conclusão: a infecção primária da corrente sanguínea configura-se como um evento adverso de significativo impacto clínico, econômico e organizacional, por estar associada ao prolongamento das internações, ao aumento da morbimortalidade e à maior demanda por recursos, impondo importante ônus aos sistemas de saúde. Contribuições para a prática: os achados reforçam a importância de políticas institucionais voltadas à segurança do paciente, bem como da adoção de práticas preventivas, visando ao fortalecimento dos desfechos assistenciais e à otimização dos recursos disponíveis.
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Referências
1. Acosta NC, Ceratti RN, Santos MS, Fantin SS, Fuzinatto F, Almeida Neto OP, et al. Central line-associated bloodstream infections in patients with COVID-19. Rev Latino-Am Enfermagem. 2024;32:e4236. doi: https://doi.org/10.1590/1518-8345.7007.4236
2. Elangovan S, Lo JJ, Xie Y, Mitchell B, Graves N, Cai Y. Impact of central-line-associated bloodstream infections and catheter-related bloodstream infections: a systematic review and meta-analysis. J Hosp Infect. 2024;152:126-37. doi: https://doi.org/10.1016/j.jhin.2024.08.002
3. Allel K, Stone J, Undurraga EA, Day L, Moore CE, Lin L, et al. The impact of inpatient bloodstream infections caused by antibiotic-resistant bacteria in low- and middle-income countries: a systematic review and meta-analysis. PLoS Med. 2023;20(6):e1004199. doi: https://dx.doi.org/10.1371/journal.pmed.1004199
4. Agência Nacional de Vigilância Sanitária (BR). Medidas de prevenção de infecção relacionada à assistência à saúde: série segurança do paciente e qualidade dos serviços de saúde [Internet]. 2017 [cited Feb 2, 2026]. Available from: https://www.gov.br/anvisa/pt-br/centraisdeconteudo/publicacoes/servicosdesaude/publicacoes/caderno-4-medidas-de-prevencao-de-infeccao-relacionada-a-assistencia-a-saude.pdf
5. Leoncio JM, Almeida VF, Ferrari RAP, Capobiango JD, Kerbauv G, Tacla MTGM. Impact of healthcare-associated infections on the hospitalization costs of children. Rev Esc Enferm USP. 2019;53:e03486. doi: https://doi.org/10.1590/S1980-220X2018016303486
6. Peters MDJ, Godfrey C, McInerney P, Munn Z, Tricco AC, Khalil H. Scoping reviews. In: Aromataris E, Lockwood C, Porritt K, Pilla B, Jordan Z. JBI manual for evidence synthesis. Adelaide: JBI; 2024. doi: https://doi.org/10.46658/JBIMES-24-09
7. Pollock D, Peters MDJ, Khalil H, McInerney P, Alexander L, Tricco AC, et al. Recommendations for the extraction, analysis, and presentation of results in scoping reviews. JBI Evid Synth. 2023;21(3):520-32. doi: http://doi.org/10.11124/JBIES-22-00123
8. Haughey BS, White SC, Seckeler M. Catheter-associated bloodstream infection incidence and outcomes in congenital cardiac surgery. Congenit Heart Dis. 2019;14(5):811-3. doi: https://doi.org/10.1111/chd.12809
9. Karagiannidou S, Zaoutis T, Maniadakis N, Papaevangelou V, Kourlaba G. Attributable length of stay and cost for pediatric and neonatal central line-associated bloodstream infections in Greece. J Infect Public Health. 2019;12(3):372-9. doi: https://doi.org/10.1016/j.jiph.2018.12.004
10. Len EK, Akkisetty R, Royal S, Brooks M, Coyle S, Gupta R, et al. Increased healthcare-associated infections in a surgical intensive care unit related to boarding non-surgical patients. Surg Infect (Larchmt). 2019;20(4):332-7. doi: https://dx.doi.org/10.1089/sur.2018.240
11. Baier C, Linke L, Eder M, Schwab F, Chaberny IF, Vonberg RP, et al. Incidence, risk factors and healthcare costs of central line-associated nosocomial bloodstream infections in hematologic and oncologic patients. PLoS One. 2020;15(1):e0227772. doi: https://doi.org/10.1371/journal.pone.0227772
12. Brown R, Burke D. The hidden cost of catheter related blood stream infections in patients on parenteral nutrition. Clin Nutr ESPEN. 2020;36:146-9. doi: https://doi.org/10.1016/j.clnesp.2020.01.001
13. Osme SF, Almeida APS, Lemes MF, Barbosa WO, Arantes A, Mendes CM, et al. Costs of healthcare-associated infections to the Brazilian public Unified Health System in a tertiary-care teaching hospital: a matched case-control study. J Hosp Infect. 2020;106(2):303-10. doi: https://dx.doi.org/10.1016/j.jhin.2020.07.015
14. Osme SF, Souza JM, Osme IT, Almeida APS, Mendes-Rodrigues C, Gontijo-Filho PP, et al. Financial impact of healthcare-associated infections on intensive care units estimated for fifty Brazilian university hospitals affiliated to the unified health system. J Hosp Infect. 2021;117:96-102. doi: https://doi.org/10.1016/j.jhin.2021.08.012
15. Khan MO, Uddin NS, Khamisani AM, Shah R. Frequency, causative organisms, excess cost and short-term outcomes of peripheral and central line associated nosocomial blood stream infection in adult patients admitted in a tertiary care hospital. Pak J Med Health Sci. 2023;16(12):521-25. doi: https://doi.org/10.53350/pjmhs20221612521
16. Hou Y, Griffin LP, Ertmer K, Bernatchez SF, Kärpänen TJ, Palka-Santini M. Effectiveness of disinfecting caps for intravenous access points in reducing central line-associated bloodstream infections, clinical utilization, and cost of care during COVID-19. Clinicoecon Outcomes Res. 2023;15:477-86. doi: https://dx.doi.org/10.2147/CEOR.S404823
17. Yu CK, Jung M, Ai C. Characteristics, costs, and outcomes associated with central-line-associated bloodstream infection and hospital-onset bacteremia and fungemia in US hospitals. Infect Control Hosp Epidemiol. 2023;44(12):1920-6. doi: https://doi.org/10.1017/ice.2023.132
18. Bezerra IL, Nassar AP Jr, Mendonça TS, Tomazini BM, Veiga VC, Arns B, et al. Patient-level cost analysis of intensive care unit-acquired infections: a prospective cohort study. J Hosp Infect. 2024;139:106-14. doi: https://doi.org/10.1016/j.jhin.2024.07.002
19. Yengudhati V, Gutowski J, Glassman S, Phillips M, Frey S, Bronstein M, et al. The differential burden of 3 health care–associated infections on hospital costs and lengths of stay: a quasi-experimental case-control observation. Am J Infect Control. 2024;52(12):1466-8. doi: https://doi.org/10.1016/j.ajic.2024.07.014
20. Centers for Medicare & Medicaid Services (US). Hospital-Acquired Condition Reduction Program [Internet]. 2024 [cited Feb 9, 2026]. Available from: https://www.cms.gov/medicare/quality/value-based-programs/hospital-acquired-conditions
21. Agência Nacional de Vigilância Sanitária (BR). Boletim Segurança do Paciente e Qualidade em Serviços de Saúde nº 32: Avaliação Nacional dos indicadores de IRAS e RM [Internet]. 2024 [cited Feb 9, 2026]. Available from: https://www.gov.br/anvisa/pt-br/centraisdeconteudo/publicacoes/servicosdesaude/paineis-analiticos/boletins-das-notificacoes-de-iras-e-outros-eventos-adversos
22. Barret D, Noble H. What are cohort studies? Evid Based Nurs. 2019;22(4):95-6. doi: https://doi.org/10.1136/ebnurs-2019-103183
23. Hasan B, Bechenati D, Bethela HM, Cho S, Rajjoub NS, Murad ST, et al. A systematic review of length of stay linked to hospital-acquired falls, pressure ulcers, central line-associated bloodstream infections, and surgical site infections. Mayo Clin Proc Innov Qual Outcomes. 2025;9(3):100607. doi: https://doi.org/10.1016/j.mayocpiqo.2025.100607
24. Pegoraro NB, Miyake AM, Rocha GMS, Boarão GP, Cruz AS, Aladino TML, et al. nfecção primária de corrente sanguínea associada a cateter venoso central em unidade de terapia intensiva neonatal: avaliação da incidência após implantação de pacotes de intervenção (bundle). BioSCI. 2024;82:e00056. doi: https://dx.doi.org/10.55684/2024.82.e00056
25. Cabrero EL, Terradas RR, Cuñado AC, Sardelli DG, López CH, Formatger DG, et al. Risk factors of catheter-associated bloodstream infection: systematic review and meta-analysis. PLoS One. 2023;18(3):e0282290. doi: https://dx.doi.org/10.1371/journal.pone.0282290
26. Rosenthal VD, Memish ZA, Shweta F, Bearman G, Lutwick LI. Preventing central line-associated bloodstream infections: a position paper of the International Society for Infectious Diseases, 2024 update. Int J Infect Dis. 2025;150:107290. doi: https://doi.org/10.1016/j.ijid.2024.107290
27. Alwazzeh MJ, Alnimr A, Al Nassri SA, Alwarthan SM, Alhajri M, Alshehail BM, et al. Microbiological trends and mortality risk factors of central line-associated bloodstream infections in an academic medical center, 2015-2020. Antimicrob Resist Infect Control. 2023;12(1):128. doi: https://doi.org/10.1186/s13756-023-01338-5
28. Devrim I, Özkul MT, Çağlar I, Oruç Y, Demiray N, Tahta N, et al. Central line bundle including split-septum device and single-use prefilled flushing syringes to prevent port-associated bloodstream infections: a cost and resource-utilization analysis. BMC Health Serv Res. 2020;20(1):336. doi: http://doi.org/10.1186/s12913-020-05221-6
29. Carmo Filho R, Carvalho GJ, Santos SM, Rabacow FM, Borges PP. Public policies, hospital management, and local development. GeSec. 2024;15(11):e4328. doi: https://doi.org/10.7769/gesec.v15i11.4328
30. Buetti N, Marschall J, Drees M, Fakih MG, Hadaway L, Maragakis LL, et al. Strategies to prevent central line-associated bloodstream infections in acute-care hospitals: 2022 update. Infect Control Hosp Epidemiol. 2022;43(5):553-69. doi: https://doi.org/10.1017/ice.2022.87
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Copyright (c) 2026 Janayna Thais Silva, Daiana Kloh Khalaf, Kariane Gomes Cezario Roscoche, Márcia Helena de Souza Freire, Shirley Boller, Bruna Costa Bueno

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