Survival rate after paraquat poisoning: impact of emergency clinical and laboratory variables
DOI:
https://doi.org/10.15253/2175-6783.20212270836Keywords:
Poisoning; Paraquat; Emergencies; Survival Rate; Amazonian Ecosystem.Abstract
Objective: to analyze the association of survival to emergency care measures, clinical symptoms and biochemical markers used for paraquat intoxicated patients. Methods: retrospective cohort, guided by the Strengthening the Reporting of Observational Studies in Epidemiology tool. The data collection and analysis protocol were based on two phases: first, with the survey of the investigation forms of exogenous poisoning from the Secretariat of Epidemiological Surveillance; second, with the analysis of information in printed medical records. Results: of the 36 (100%) patients investigated, 19 (53.0%) survived; regarding the clinical manifestations, there was statistical significance for the respiratory system (p=0.003); regarding the biochemical variables, there was statistical significance for liver enzymes. The initial emergency measures 13(56.5%) of survivors received gastric lavage with activated charcoal. Conclusion: we observed a lack of efficacy of the impacts of emergency care measures and medications in increasing patient survival.
References
Lu X, Wu D, Gao Y, Zhang M. Lung ultrasound predicts acute respiratory distress syndrome in patients with paraquat intoxication. Hong Kong J Emerg Med. 2017; 24(6):275-81. doi: https://doi.org/10.1177/1024907917735087
Xu Y, Chen Y, Le J, Chen Z, Wang H, Zhang P, et al. Analysis of prognostic factors in patients with paraquat poisoning for better therapy regimen. Res Sq. 2020. doi: https://doi.org/10.21203/rs.3.rs-37897/v1
Fernando M, Camilo M, Orlando P. Paraquat intoxication as a cause of multiple organ failure: report of a case and review of the literature. MOJ Toxicol. 2018; 4(4):247-53. doi: https://doi.org/10.15406/mojt.2018.04.00108
Isha IT, Alam ZN, Shaha BK, Bari MS, Bari MZJ, Chowdhury FR. Paraquat induced acute kidney injury and lung fibrosis: a case report from Bangladesh. BMC Res Notes. 2018; 11(1):344. doi: https://doi.org/10.1186/s13104-018-3425-3
Arora N, Dhibar DP. Quaternion of paraquat poisoning: icterus, oral ulceration, acute respiratory and renal failure. Postgrad Med J. 2020. doi: https://dx.doi.org/10.1136/postgradmedj-2020-139271
Subbiah R, Tiwari RR. The herbicide paraquat-induced molecular mechanisms in the development of acute lung injury and lung fibrosis. Crit Rev Toxicol. 2021; 51(1):36-64. doi: https://dx.doi.org/10.1080/10408444.2020.1864721
Su Y, Liu W, Dong G, Qian Z, Gurram N, Liu E, et al. Investigation of simple, objective, and effective indicators for predicting acute paraquat poisoning outcomes. Toxicol Industrial Health. 2020; 36(6):417-26. https://doi.org/10.1177/0748233720933522
Souza LP, Lima MG, Viana RAPP, Romanholo RA, Vasconcellos C. Intoxicação parenteral por herbicida: estamos preparados para o cuidar? Nursing (São Paulo). 2020; 23(267):4486-93. doi: https://doi.org/10.36489/nursing.20201231267p4486-4501
Ministério da Saúde (BR). Sistema Nacional de Informações Tóxico-Farmacológicas [Internet]. 2017 [cited Apr 20, 2021]. Available from: https://sinitox.icict.fiocruz.br/sites/sinitox.icict.fiocruz.br/files//2%20-%20Agrotoxico%20Uso%20Agricola1.pdf
Elm EV, Altman DL, Egger M, Pocock SJ, Gotzche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. PLoS Med. 2007; 4(10):e296. doi: https://doi.org/10.1016/j.jclinepi.2007.11.008
Tyagi N, Singh R. Paraquat-induced oxidative stress and lung inflammation. In: Chakraborti S. Oxidative stress in lung diseases. Springer [Internet]. 2020 [cited Apr 20, 2021]; 245-70. Available from: https://bityli.com/pBJt9
Oghabian Z, Williams J, Mohajeri M, Nakhaee S, Shojaeepour S, Amirabadizadeh A, et al. Clinical features, treatment, prognosis, and mortality in paraquat poisonings: a hospital-based study in Iran. J Res Pharm Pract. 2019; 8(3):129. doi: https://doi.org/10.4103/2319-9644.274162
Souza LPS, Vasconcellos C, Romanholo RA, Silva JCS. Características epidemiológicas e clínicas de vítimas intoxicadas pelo herbicida Paraquat no cone sul da Amazônia Legal-Brasil. Inter Am J Med Health 2021; 4:e202101007. doi: https://doi.org/10.31005/iajmh.v4i.178
Hu L, Li H, Cai Z, Lin F, Hong G, Chen H, et al. A new machine-learning method to prognosticate paraquat poisoned patients by combining coagulation, liver, and kidney indices. PloS One. 2017; 12(10):e0186427. doi: https://doi.org/10.1371/journal.pone.0186427
Elenga N, Merlin C, Le Guern R, Kom-Tchameni R, Ducrot Y-M, Pradier M, et al. Clinical features and prognosis of paraquat poisoning in French Guiana: a review of 62 cases. Medicine. 2018; 97(15):e9621. doi: https://dx.doi.org/10.1097%2FMD.0000000000009621
Wang H-R, Pan J, Shang A-D, Lu Y-Q. Time-dependent haemoperfusion after acute paraquat poisoning. Sci Rep. 2017; 7(1):1-8. doi: https://doi.org/10.1038/s41598-017-02527-0
Kavousi-Gharbi S, Jalli R, Rasekhi-Kazerouni A, Habibagahi Z, Marashi SM. Discernment scheme for paraquat poisoning: A five-year experience in Shiraz, Iran. World J Exp Med. 2017; 7(1):31. doi: https://doi.org/10.5493/wjem.v7.i1.31
Zhao X, Xiao Y, Zhu J, Xu Z, Liu L, Zhang J. Prognostic comparison of goal-oriented hemoperfusion and routine hemoperfusion combined with continuous venovenous hemofiltration for paraquat poisoning. J Int Med Res. 2018; 46(3):1091-102. doi: https://doi.org/10.1177/0300060517734917
Wang Y, Chen Y, Mao L, Zhao G, Hong G, Li M, et al. Effects of hemoperfusion and continuous renal replacement therapy on patient survival following paraquat poisoning. PLoS One. 2017; 12(7):e0181207. doi: https://doi.org/10.1371/journal.pone.0181207
Martins BF, Hungaro AA, Santos JAT, Meschial WC, Correia LM, Oliveira MLF. Intoxicação por raticida em um Centro de Assistência Toxicológica. Rev Rene. 2016; 17(1):3-9. doi: https://doi.org/10.15253/2175-6783.2016000100002
